A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex. The disease is EFO_0007459 (pyruvate decarboxylase deficiency). Also known as: Pyruvate Dehydrogenase Complex Deficiency Disease, deficiency of pyruvic dehydrogenase, pyruvate dehydrogenase complex deficiency disease, pyruvate dehydrogenase deficiency.