anti-centromere-antibody-positive systemic scleroderma (Experimental Factor Ontology term EFO_0008536) is a sub-type of systemic scleroderma characterised by the presence of antibodies to centromere proteins. Also known as: ACA-positive systemic scleroderma, ACA-positive systemic sclerosis, anti-centromere-antibody-positive systemic sclerosis.