Autosomal recessive spastic paraplegia type 57 (SPG57) is an extremely rare, complex type of hereditary spastic paraplegia, characterized by onset in infancy of pronounced leg spasticity (leading to the inability to walk independently), reduced visual acuity due to optic atrophy, and distal wasting of the hands and feet due to an axonal demyelinating sensorimotor neuropathy. SPG57 is caused by mutations in the TFG  gene (3q12.2) encoding protein TFG, which is thought to play a role in ER microtubular architecture and function. The disease is Autosomal recessive spastic paraplegia type 57 (Experimental Factor Ontology entry EFO_0009017). Also known as: SPG57, Spastic paraplegia due to partial TFG deficiency.