Spastic paraplegia-76 is an autosomal recessive neurologic disorder characterized by young-adult onset of slowly progressive spasticity of the lower limbs resulting in gait difficulties. Most affected individuals have upper limb involvement and additional features such as foot deformities and dysarthria. Cognition is unaffected (summary by Gan-Or et al., 2016). The disease is Experimental Factor Ontology entry EFO_0009019 (Autosomal recessive spastic paraplegia type 76). Also known as: SPG76.