EFO_0009148 (acth-independent macronodular adrenal hyperplasia 2) can be described as follows. ACTH-independent macronodular adrenal hyperplasia-2 is an autosomal dominant tumor susceptibility with syndromic incomplete penetrance, as a second hit to the ARMC5 gene is required to develop macronodular hyperplasia (Assie et al., 2013). Also known as: AIMAH2, primary macronodular adrenal hyperplasia.