A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine. The disease is EFO_0009909 (stage 5 chronic kidney disease). Also known as: End stage renal disease, End stage renal failure, End-stage renal failure, chronic renal failure, end-stage renal disease.