A disorder characterized by multiple mesenchymal tumors of the gastrointestinal tract, including gastrointestinal stromal tumor, inflammatory fibroid polyps, and fibroid tumors. Additional features are coarse facies and skin, broad hands and feet, and premature tooth loss. GISTPS is an autosomal dominant disease with incomplete penetrance. Gastrointestinal stromal tumor and inflammatory fibroid polyps may also occur in isolation. The disease is GIST-plus syndrome (EFO_0010279). Also known as: gastrointestinal stromal tumor, polyps, multiple and recurrent inflammatory fibroid, gastrointestinal.