Experimental Factor Ontology entry EFO_0011021 (BRCA1 mutation carier status) is determination of the presence or absence of known harmful mutation(s) in the BRAC1 gene. BRCA1/BRCA2 genes play a central role in DNA repair and their mutations increase sensitivity to DNA-damaging agents. BRCA1/BRCA2 germline mutations significantly increase the risk of breast and ovarian cancer. Also known as: BRCA1 carrier status, BRCA1 mutation status.