A bronchiectasis inflammatory endotype characterized by concurrent neutrophilic and eosinophilic (type 2/Th2) inflammation, with co-expression of neutrophil-associated markers (neutrophil elastase, IL-8) and eosinophilic markers (IL-5, IL-13, FeNO). This endotype represents a distinct biological subgroup associated with increased exacerbation risk and potential responsiveness to combined therapeutic strategies. The disease or phenotype is EFO_0920037 (mixed granulocytic bronchiectasis). Also known as: mixed neutrophilic-eosinophilic bronchiectasis.