Severe systemic manifestation of trauma and ischemia involving soft tissues, principally skeletal muscle, due to prolonged severe crushing. It leads to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uremia. The disease is Experimental Factor Ontology term EFO_1001299 (Crush Syndrome). Also known as: Bywater's syndrome, traumatic rhabdomyolysis.