Experimental Factor Ontology entry EFO_1001478 (systemic inflammatory response syndrome) can be described as follows. SIRS is a serious condition related to systemic inflammation, organ dysfunction, and organ failure. It is a subset of cytokine storm, in which there is abnormal regulation of various cytokines. SIRS is also closely related to sepsis, in which patients satisfy criteria for SIRS and have a suspected or proven infection. Also known as: Inflammatory Response Syndrome, Systemic, SIRS, Sepsis Syndrome.