Cafe-au-lait spots are hyperpigmented lesions that can vary in color from light brown to dark brown with smooth borders and having a size of 1.5 cm or more in adults and 0.5 cm or more in children. The phenotype is Human Phenotype Ontology term HP_0000957 (Cafe-au-lait spot). Also known as: Cafe au lait spots, Cafe-au-lait macule, Cafe-au-lait macules.