Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis. The phenotype is Human Phenotype Ontology entry HP_0007404 (Nonepidermolytic palmoplantar hyperkeratosis). Also known as: Nonepidermolytic palmoplantar keratoderma.