HP_0008209 (Premature ovarian insufficiency) is amenorrhea due to loss of ovarian function before the age of 40. Primary ovarian insuficiency (POI) is a state of female hypergonadotropic hypogonadism. It can manifest as primary amenorrhea with onset before menarche or secondary amenorrhea. Also known as: Climacterium praecox, Early menopause, Hypergonadotropic amenorrhea, Menopause praecox, Premature menopause, Premature ovarian failure, Primary ovarian insufficiency.