Reduced muscle fiber perlecan (Human Phenotype Ontology entry HP_0030122) is immunohistochemistry reveals reduced perlecan protein in the muscle biopsy. Perlecan is a basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) also known as heparan sulfate proteoglycan 2 (HSPG2). Also known as: Reduced muscle fibre perlecan.