The Immunodeficiency, Centromeric region instability, Facial anomalies syndrome (ICF) is a rare autosomal recessive disease characterized by immunodeficiency, although B cells are present, and by characteristic rearrangements in the vicinity of the centromeres (the juxtacentromeric heterochromatin) of chromosomes 1 and 16 and sometimes 9. The disease is Monarch Disease Ontology term MONDO_0000133 (immunodeficiency-centromeric instability-facial anomalies syndrome). Also known as: immunodeficiency-centromeric instability-facial anomalies.