A disorder in which there is a failure to regenerate the active glucocorticoid cortisol from cortisone via 11beta-HSD1. The resulting lack of cortisol regeneration stimulates ACTH-mediated adrenal hyperandrogenism, with males manifesting in childhood with precocious pseudopuberty and females presenting in adolescence and early adulthood with hirsutism, oligoamenorrhea, and infertility. The disease is cortisone reductase deficiency (MONDO_0000193, a Monarch Disease Ontology id). Also known as: 11-beta-hydroxysteroid dehydrogenase deficiency type 1, CORTRD, deficiency of (R)-20-hydroxysteroid dehydrogenase, deficiency of cortisone reductase, hyperandrogenism due to cortisone reductase deficiency.