cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 (MONDO_0000914) is a CADASIL characterized by migraine, strokes, and white matter lesions that has material basis in heterozygous mutation in the NOTCH3 gene on chromosome 19p13. Also known as: CADASIL, CADASIL 1, CADASIL syndrome, CADASIL type 1, CADASIL1, CASIL, autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy type 1, cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1.