An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation. The disease is Monarch Disease Ontology identifier MONDO_0000984 (thalassemia). Also known as: sickle-cell thalassemia with crisis, sickle-cell thalassemia without crisis, thalassemia Hb-S disease with crisis, thalassemia Hb-S disease without crisis.