A syndrome characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure. The disease is Monarch Disease Ontology entry MONDO_0001956 (capillary leak syndrome). Also known as: AVLS, CLS, Clarkson disease, SCLS, Systemic Capillary Leak Syndrome, acute vascular leak syndrome, capillary hyperpermeability syndrome, idiopathic capillary leak syndrome.