A genetically heterogenous inherited disorder characterized by abnormalities in the metabolism of lipids and proteins. Signs and symptoms usually appear early in life and vary from mild to life threatening. They include vomiting, dehydration, hypotonia, developmental delays, hepatomegaly, lethargy, intellectual disabilities, and chronic kidney disease. The disease is Monarch Disease Ontology identifier MONDO_0002012 (methylmalonic acidemia). Also known as: methylmalonic aciduria.