A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs in the parotid gland and less often in the submandibular gland and minor salivary gland. Patients usually present with a history of a long-standing mass which recently had undergone rapid growth. The prognosis depends on the invasiveness of the malignant component. Patients with non-invasive or minimally invasive tumors usually have a good prognosis following surgical resection. Invasive tumors are usually aggressive and are associated with recurrences and metastases. The disease is carcinoma ex pleomorphic adenoma (MONDO_0002472, a Monarch Disease Ontology identifier). Also known as: carcinoma ex pleomorphic adenoma (morphologic abnormality), carcinoma in pleomorphic adenoma.