Monarch Disease Ontology term MONDO_0002625 (Ewing sarcoma of bone) is a small round cell bone tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It often affects the diaphysis or metaphyseal-diaphyseal portion of long bones. Clinical findings include pain and a mass in the involved area. fever, anemia, leukocytosis, and an increased sedimentation rate are often seen. X-ray examination reveals osteolytic lesions. The prognosis depends on the stage, anatomic location, and size of the tumor. Also known as: Ewing's sarcoma of bone, Ewing's sarcoma, osseous, Ewing's sarcoma/bone peripheral primitive neuroectodermal tumor, Ewing's sarcoma/bone peripheral primitive neuroectodermal tumour, bone Ewing sarcoma, bone Ewing's sarcoma, bone localised Ewing sarcoma, bone localised Ewing's sarcoma.