A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor. The disease is MONDO_0003210 (intrahepatic cholangiocarcinoma). Also known as: ICC, cholangiocarcinoma, intrahepatic, malignant, intrahepatic Cholangiocellular carcinoma, intrahepatic bile duct cancer (cholangiocarcinoma), intrahepatic bile duct carcinoma, intrahepatic carcinoma of bile duct, intrahepatic carcinoma of the bile duct, intrahepatic cholangiocarcinoma (bile duct cancer).