Monarch Disease Ontology entry MONDO_0003586 (esophagus liposarcoma) is a malignant adipose tissue neoplasm of the esophagus, characterized by multivacuolated lipoblasts with hyperchromatic nuclei, a solid pattern of growth, and a rich vascular network. It arises from the mucosal and submucosal layers of the lower esophagus. Clinical presentation includes progressive dysphagia, nausea, throat discomfort, and foreign body sensation. Also known as: esophageal liposarcoma, liposarcoma of esophagus, liposarcoma of oesophagus, liposarcoma of the esophagus, liposarcoma of the oesophagus.