Monarch Disease Ontology identifier MONDO_0003608 (optic atrophy) is a disorder characterized by loss of optic nerve fibers. It may be inherited or acquired. Acquired causes include ischemia, optic nerve neuropathy, glaucoma, trauma, radiation, brain tumors, and multiple sclerosis. It leads to vision disturbances. Also known as: atrophy of optic disc, atrophy of optic disk.