Monarch Disease Ontology entry MONDO_0004781 (acute myocardial infarction) is necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations. Also known as: acute myocardial infarction (disease), myocardial infarction (disease), acute.