systemic sclerosis (MONDO_0005100) is a chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension. Also known as: PSS (progressive systemic sclerosis), SSc, SSc, diffuse sclerosis, Scleroderma (& [systemic sclerosis]), Scleroderma syndrome, Scleroderma, diffuse, Scleroderma, systemic, Systemic Scleroderma.