Monarch Disease Ontology entry MONDO_0005252 (heart failure) is inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. Also known as: cardiac failure, cardiac insufficiency, failure, heart, insufficiency, Cardiac.