A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene. The disease is nut midline carcinoma (MONDO_0005563). Also known as: Midline carcinoma of children and Young adults with NUT rearrangement, NMC, NUT Midline carcinoma, NUT carcinoma, carcinoma with t(15;19)(q13;p13.1) translocation, nuclear protein in testis midline carcinoma.