A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma. The disease is colorectal cancer (Monarch Disease Ontology entry MONDO_0005575). Also known as: cancer of colorectum, cancer of large bowel, cancer of large intestine, cancer of the large bowel, colon cancer, advanced, somatic, colon cancer, somatic, colorectal cancer with chromosomal instability, somatic, colorectal cancer, autosomal dominant, somatic mutation.