A group of skin disorders including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). The disease is severe cutaneous adverse reaction (Monarch Disease Ontology identifier MONDO_0005594). Also known as: SCAR.