An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present. The disease is Lynch syndrome (Monarch Disease Ontology term MONDO_0005835). Also known as: Hereditary colorectal endometrial cancer syndrome, Hereditary non-polyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2), Hereditary nonpolyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2), familial non-polyposis colon cancer (hMSH2, hMLH1, hPMS1, hPMS2), hereditary defective mismatch repair syndrome.