An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. The disease is Monarch Disease Ontology term MONDO_0005893 (pancreatic endocrine carcinoma). Also known as: Pancreatic Neuroendocrine cancer, carcinoma of endocrine pancreas, carcinoma, islet cell, malignant, endocrine pancreas carcinoma, high grade pancreatic neuroendocrine carcinoma, high-grade pancreatic neuroendocrine carcinoma, islet cell cancer, islet cell carcinoma.