A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC. The disease is MONDO_0006082 (anal squamous cell carcinoma). Also known as: anal squamous cell cancer, anus squamous cell carcinoma, epidermoid anal carcinoma, epidermoid carcinoma of anus, epidermoid carcinoma of the anus, squamous cell anal carcinoma, squamous cell carcinoma - anus, squamous cell carcinoma of anus.