A carcinoma that arises from a pleomorphic adenoma in the major salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive. The disease is major salivary gland carcinoma ex pleomorphic adenoma (MONDO_0006285). Also known as: carcinoma ex pleomorphic adenoma of Major salivary gland, carcinoma ex pleomorphic adenoma of the Major salivary gland, major salivary gland salivary gland carcinoma ex pleomorphic adenoma.