An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant large cells. The disease is Monarch Disease Ontology term MONDO_0006347 (pancreatic large cell neuroendocrine carcinoma). Also known as: large cell neuroendocrine carcinoma of pancreas, pancreas large cell neuroendocrine carcinoma, pancreatic large cell NEC, pancreatic large cell NEC G3.