central pontine myelinolysis (Monarch Disease Ontology identifier MONDO_0006692) is a central nervous system disorder caused by demyelination within the central basis pontis of the brain. It is characterized by spastic quadriplegia, pseudobulbar palsy and encephalopathy. It is observed in patients with severe hyponatremia, particularly when the hyponatremia is corrected too rapidly. Also known as: osmotic demyelination syndrome.