Monarch Disease Ontology entry MONDO_0006770 (giant cell reparative granuloma) is a rare tumor-like lesion of the hands and feet characterized by the presence of hemorrhagic fibrous tissue, hemosiderin deposition, osteoclast-like giant cells which are irregularly distributed, and reactive bone formation. Pain and swelling are the most frequent symptoms. It may recur following curettage, but is usually cured after a second procedure. Also known as: GCLSB, central giant cell (reparative) granuloma, central giant cell granuloma, central giant cell reparative granuloma of jaw, giant cell lesion of small bones.