type III hypersensitivity disease (MONDO_0007004, a Monarch Disease Ontology entry) is group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides serum sickness and the arthus reaction, evidence supports a pathogenic role for immune complexes in many other immune system diseases including glomerulonephritis, systemic lupus erythematosus (lupus erythematosus, systemic) and polyarteritis nodosa. Also known as: disorder of type III hypersensitivity, immune complex disease, type 3 hypersensitivity reaction, type III hypersensitivity, type III hypersensitivity reaction.