A syndrome characterized by branchial arch anomalies (branchial clefts, fistulae, cysts), hearing impairment (malformations of the auricle with pre-auricular pits, conductive or sensorineural hearing impairment), and renal malformations (urinary tree malformation, renal hypoplasia or agenesis, renal dysplasia, renal cysts). The disease is Monarch Disease Ontology term MONDO_0007029 (branchio-oto-renal syndrome). Also known as: Branchio-Oto-renal syndrome, Branchio-otorenal dysplasia, Melnick-Fraser syndrome, branchiootorenal dysplasia, branchiootorenal syndrome.