An acrocephalosyndactylia characterized by abnormalities in the bones of the legs, congenital heart defects and craniofacial defects and craniosynostosis. The patients suffer from cyanosis and other respiratory and breathing infections. The disease is MONDO_0007040 (Sakati-Nyhan syndrome). Also known as: ACPS with leg hypoplasia, Sakati-Nyhan-Tisdale syndrome, acrocephalopolysyndactyly type 3, acrocephalopolysyndactyly type III.