Hereditary painful callosities is a nummular palmoplantar keratoderma characterized by the development of painful keratotic lesions over pressure points in hands and feet. A few families have been described. Transmission is autosomal dominant. Successful analgesia can be obtained with tretinoin. The disease is hereditary painful callosities (MONDO_0007248). Also known as: PPK nummularis, Plamoplantar hyperkeratosis nummularis, Plamoplantar keratoderma nummularis, keratosis palmoplantaris nummularis.