A basal subtype of epidermolysis bullosa simplex (EBS). The disease is characterized by blisters occurring mainly on the palms and soles, exacerbated by warm weather. The disease is MONDO_0007551 (epidermolysis bullosa simplex 1C, localized). Also known as: EBS-loc, epidermolysis bullosa simplex of palms and soles, epidermolysis bullosa simplex, Weber-Cockayne type, localised epidermolysis bullosa simplex, localized epidermolysis bullosa simplex.