Any holoprosencephaly in which the cause of the disease is a mutation in the SHH gene. The disease is Monarch Disease Ontology term MONDO_0007733 (holoprosencephaly 3). Also known as: HLP3, HPE3, SHH holoprosencephaly, Shh holoprosencephaly, holoprosencephaly caused by mutation in SHH, holoprosencephaly caused by mutation in Shh, holoprosencephaly type 3.