A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma chylomicrons and triglycerides contained in very-low-density lipoproteins. Type V hyperlipoproteinemia is often associated with diabetes mellitus and is not caused by reduced lipoprotein lipase activity as in hyperlipoproteinemia type I. The disease is hyperlipoproteinemia type V (Monarch Disease Ontology entry MONDO_0007762). Also known as: Fredrickson type V lipaemia, HLP type 5, familial APOA5 deficiency, familial apolipoprotein A-V deficiency, familial apolipoprotein A5 deficiency, familial hyperlipoproteinemia type V, familial type 5 hyperlipoproteinemia, major hyperlipidemia.