A condition of decreased or absent presence or activity of signal transducer and activator of transcription 3 protein. Deficiency of this protein is associated with hyper-IgE syndrome. The disease is Monarch Disease Ontology term MONDO_0007818 (hyper-IgE recurrent infection syndrome 1, autosomal dominant). Also known as: AD hyperimmunoglobulin E syndrome, AD-HIES, Buckley syndrome, HIES autosomal dominant, HIES, autosomal dominant, JOB syndrome, Job syndrome autosomal dominant, Job's syndrome.