Familial Partial lipodystrophy, Dunnigan type (FPLD2) is a rare form of genetic lipodystrophy characterized by a loss of subcutaneous adipose tissue from the trunk, buttocks and limbs; fat accumulation in the neck, face, axillary and pelvic regions; muscular hypertrophy; and usually associated with metabolic complications such as insulin resistance, diabetes mellitus, dyslipidemia and liver steatosis. The disease is Monarch Disease Ontology entry MONDO_0007906 (familial partial lipodystrophy, Dunnigan type). Also known as: Dunnigan syndrome, FPLD2, familial lipodystrophy of limbs and lower trunk, familial partial lipodystrophy Dunnigan type, familial partial lipodystrophy type 2, reverse partial lipodystrophy.