Pai syndrome is an idiopathic developmental disorder characterized by median cleft of the upper lip (MCL), midline polyps of the facial skin and nasal mucosa, and pericallosal lipomas. Hypertelorism with ocular anomalies are also observed, generally with normal neuropsychological development. The disease is Pai syndrome (Monarch Disease Ontology identifier MONDO_0007956). Also known as: median cleft of the upper lip-corpus callosum lipoma-cutaneous polyps syndrome.