The Melkersson-Rosenthal syndrome is a rare disorder characterized by a triad of recurrent orofacial swelling, relapsing facial paralysis and fissured tongue and onset in childhood or early adolescence. It has an estimated incidence of 8/10,000. The etiology is unknown but hereditary predisposition is suspected. The disease is MONDO_0007969 (Melkersson-Rosenthal syndrome). Also known as: Melkersson's syndrome, cheilitis granulomatosa of Mescher-Melkersson-Rosenthal.